Senior Full-Stack Engineer at Simulations Plus – US | Jobyssey

Simulations Plus stands as a global leader in model-informed and AI-accelerated drug development. We create value for our clients by accelerating the discovery, development, and commercialization of pharmaceuticals and other products through innovative science-based software and consulting solutions.

Leadership truly cares about maintaining a positive culture and employee well-being. We offer fully remote work, flexible schedules, and generous vacation policy along with affordable health coverage, annual bonus, and more! Check out how much our employees love working here: .

The Senior Full-Stack Engineer is a versatile contributor, part of a small department whose charter spans both web/SaaS and AI/agents products. The role will ship features across the full stack — backend, frontend, and LLM-integrated surfaces — wherever the team's most pressing implementation work lands in a given cycle. It's a high-variety role for an engineer who wants to build real depth across web platform and applied-AI engineering, on a deliberately lean team that's growing quickly and intentionally.

Department: Product and Technology

Internal Grade: 10

Direct Reports: No

Status: Exempt

Location: Remote

Job Responsibilities:

Feature Delivery Across the Stack
- Own features end-to-end across Node.js and Express backends and React/Tailwind frontends
- Build the APIs, UI, and data flows behind real customer-facing functionality
- Contribute to the data, auth, and service patterns the platform builds on
AI Feature Integration
- Integrate LLM-powered functionality into product surfaces, working alongside the team's AI lead
- Wire frontends to LLM and MCP endpoints; handle streaming, errors, and degraded states gracefully
- Contribute to evals, fixtures, and tooling that support the AI side of the team
Team Impact
- Bring full-stack range to a team that values flexibility across backend, frontend, and AI
- Contribute to code reviews, documentation, and the team's shared engineering practices
- Apply AI coding tools effectively as part of daily engineering workflow
Other Duties as Assigned

Required Qualifications:

3+ years of professional software engineering experience, with shipped full-stack work in production
Proficiency in JavaScript or TypeScript across Node.js backend and React frontend
Practical experience with document or NoSQL databases such as MongoDB
Comfort building and consuming REST APIs and JSON contracts
Genuine interest in agents, MCP, and applied AI, and the drive to build real expertise in those areas
Fluency using AI coding tools (Claude, Cursor, Copilot) in daily workflow

Preferred Qualifications:

Familiarity with Anthropic, OpenAI, or other LLM provider SDKs
Exposure to MCP, agent frameworks, or LLM-integrated product features
Experience with cloud infrastructure (AWS preferred) and CI/CD pipelines
Experience in regulated-software environments (SOC 2, HIPAA, GxP, 21 CFR Part 11) or life-sciences SaaS
Familiarity with Passport, OAuth, OIDC, or comparable auth patterns

Education:

Bachelor's degree in computer science, engineering, or related field preferred
Relevant technical certifications welcomed

Come join the happiest employees in the industry by visiting and apply today!

Senior Full-Stack Engineer

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