Principal Program Manager, Enterprise Integration

McKesson is an impact-driven, Fortune 10 company that touches virtually every aspect of healthcare. We are known for delivering insights, products, and services that make quality care more accessible and affordable. Here, we focus on the health, happiness, and well-being of you and those we serve – we care.

What you do at McKesson matters. We foster a culture where you can grow, make an impact, and are empowered to bring new ideas. Together, we thrive as we shape the future of health for patients, our communities, and our people. If you want to be part of tomorrow’s health today, we want to hear from you.

McKesson is seeking a strategic and results-driven Principal, Program Manager, Enterprise Integration to lead large-scale enterprise integration, modernization, and transformation initiatives across our technology ecosystem. This role oversees highly complex, cross-functional programs spanning cloud migration, application integration, managed file transfer, middleware modernization, and enterprise platform strategy.

You will partner with technology executives, business leaders, architecture teams, and strategic partners to deliver critical transformation programs that enable business growth, operational excellence, regulatory compliance, and long-term platform optimization. You will be responsible for portfolio governance, financial stewardship, modernization roadmaps, and executive alignment across multiple business units.

What You'll Do

• Lead enterprise-wide, cross-functional integration and modernization programs from strategy through execution, ensuring on-time, on-budget, and high-quality delivery.
• Drive major transformation initiatives, including MuleSoft platform evolution, middleware modernization, cloud migration programs, IBM MFT/MQ modernization, SAP BODS upgrades, and Integration-as-a-Service strategies.
• Develop and manage multi-year program roadmaps, dependencies, risks, and delivery metrics across multiple technology and business organizations.
• Establish portfolio governance and executive reporting frameworks that provide visibility into program health, outcomes, value realization, and investment priorities.
• Lead strategic vendor and managed services relationships, including performance management, capacity planning, SOW governance, KPI tracking, and resource optimization.
• Drive platform rationalization and Total Cost of Ownership (TCO) optimization through technology lifecycle planning, licensing strategy, and vendor negotiations.
• Partner with Enterprise Architecture Review Board (EARB), security, compliance, and audit teams to ensure adherence to enterprise standards and regulatory requirements.
• Align senior stakeholders across Enterprise & Corporate, NAPD, MMS, CMM, and Technology leadership organizations to achieve strategic business objectives.

Basic Requirements

• 13+ years of experience in IT program management, enterprise transformation, integration platforms, cloud migration, or technology portfolio leadership.
• Bachelor's degree in Information Technology, Computer Science, Engineering, Information Systems, Business, or a related field, or equivalent experience.
• Experience with MuleSoft, IBM MQ, IBM MFT, SAP BODS, Azure, GCP, API integration platforms, or enterprise middleware technologies.
• Experience leading large-scale, enterprise-wide technology transformation programs with executive-level visibility.
• Proven experience managing complex cross-functional portfolios involving architecture, engineering, operations, security, and business stakeholders.
• Experience managing budgets, forecasts, financial planning, and portfolio investment decisions.
• Experience working with enterprise integration technologies, middleware platforms, APIs, cloud migration initiatives, or application modernization programs.
• Demonstrated experience overseeing external partners, managed service providers, or strategic technology vendors.
• Strong executive communication, stakeholder management, governance, and risk management capabilities.
• Experience supporting compliance and audit requirements including ITGC, SOX, HIPAA, DSCSA, or similar regulatory frameworks.
• Experience developing business cases, ROI analyses, and TCO-based investment recommendations.
• Strong experience managing vendor relationships.

Preferred Skills/Experience

• Strong experience working with the Boomi platform
• Experience leading cloud migration and modernization programs in highly regulated environments.
• Knowledge of enterprise architecture governance and EARB processes.
• Strong understanding of platform operating models, capacity planning, resource management, and technology portfolio governance.
• PMP, PgMP, SAFe, Agile, ITIL, or comparable program management certifications.
• Experience leading geographically distributed teams and large-scale managed services engagements.

We are proud to offer a competitive compensation package at McKesson as part of our Total Rewards. This is determined by several factors, including performance, experience and skills, equity, regular job market evaluations, and geographical markets. The pay range shown below is aligned with McKesson's pay philosophy, and pay will always be compliant with any applicable regulations. In addition to base pay, other compensation, such as an annual bonus or long-term incentive opportunities may be offered. For more information regarding benefits at McKesson, please click here.

Our Base Pay Range for this position

$170,100 - $283,500

McKesson has become aware of online recruiting-related scams in which individuals who are not affiliated with or authorized by McKesson are using McKesson’s (or affiliated entities, like CoverMyMeds or RxCrossroads) name in fraudulent emails, job postings or social media messages. In light of these scams, please bear the following in mind:

McKesson Talent Advisors will never solicit money or credit card information in connection with a McKesson job application.

McKesson Talent Advisors do not communicate with candidates via online chatrooms or using email accounts such as Gmail or Hotmail. Note that McKesson does rely on a virtual assistant (Gia) for certain recruiting-related communications with candidates.

McKesson job postings are posted on our career site: .

McKesson is an Equal Opportunity Employer

McKesson provides equal employment opportunities to applicants and employees, without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, age, genetic information, or any other legally protected category. For additional information on McKesson’s full Equal Employment Opportunity policies, visit our Equal Employment Opportunity page.

McKesson is committed to being an Equal Employment Opportunity Employer and offers opportunities to all job seekers including job seekers with disabilities. If you need a reasonable accommodation to assist with your job search or application for employment, please contact us by sending an email to (United States) [email protected] or (Canada) [email protected]. Resumes or CVs submitted to this email box will not be accepted.

Join us at McKesson!