Postdoctoral Fellow – Next-Gen Sequencing Systems, Research & Early Development

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

At Roche, we are developing the next-generation of sequencing systems. By accelerating clinical research, streamlining workflows, and expanding assay menus, we are also broadening access to genomic data and lowering barriers to adoption. From robust sample isolation and preparation tools to novel sequencing technology and advanced bioinformatics, we are developing differentiated, highly integrated end-to-end solutions for next-generation sequencing workflows.

We are seeking a talented and highly motivated Postdoctoral Fellow with a proven track record of excellence in developing novel technology for biological applications. Joining our Systems Technology Group, you will play a major role in the Research and Early Development of new technology, devices, and instruments associated with our next-generation DNA sequencing and molecular diagnostic platforms.

At the heart of these instruments are highly integrated microfluidic systems capable of automating intricate workflows and handling complex biochemistry. To gear up for these ambitious goals, your near-term focus will involve deep, hands-on training with our foundational efforts. You will assist with current projects to master our chemistry, materials, and methods, gaining critical expertise in how we design, fabricate, bond, simulate, operate, characterize, and troubleshoot complex systems and processes.

This is a hands-on, interdisciplinary role designed to bridge the gap between biochemical applications and cutting-edge instrumentation. Collaborating closely with a small, agile team and the broader organization, you will solve challenging problems, invent new technology, and ultimately advance the state-of-the-art in DNA sequencing systems.

The Opportuniity:

• You will design, fabricate, and assemble custom devices, fixtures, and breadboards using various rapid prototyping tools, including custom equipment.

• You will develop and implement microfabrication processes, including photolithography, etching, drilling, bonding, and dicing—and utilize precision metrology instruments to characterize components and evaluate manufacturing methodologies.

• You will create and characterize new materials and bonding methodologies.

• You will test, characterize, and troubleshoot complex fluidic systems and devices. Develop and optimize workflows on these systems while collecting, analyzing, and interpreting data to drive technical progress.

• You will generate comprehensive test plans, protocols, technical reports and invention disclosures to document findings and methodology.

• You will select, procure, install, validate, operate, repair, and maintain lab/fab equipment and custom instrumentation.

Who You Are:
(Required)

• You have a Ph.D. in Bioengineering or a closely related discipline with a thesis focused on solving a molecular biology problem with clever engineering.

• You have a solid understanding of physics, engineering, chemistry, molecular biology and sequencing fundamentals.

• You have demonstrated experience with advanced microfabrication techniques (lithography, thin-film deposition, wet/dry etching, and thermal fusion bonding processes).

• You have demonstrated success porting complex biochemical assays or workflows onto novel fluidic systems and optimizing performance using a systematic approach.

• You have a solid publication record, including at least one first-authored and peer-reviewed publication in a top-tier journal.

• You have demonstrated experience with Python scripting for instrument hardware control.

• You have a demonstrated interest regarding market trends; you have a foundational knowledge of our peers work.

Preferred:

• You have experience designing and testing microfluidic systems with active components and integrated sensors.

• You have experience building, operating, and troubleshooting fixtures or breadboards with fluidic, pneumatic, thermal, and optical subsystems.

• You are proficient in operating and interpreting data from analytical instruments (e.g., qPCR, dPCR, Bioanalyzer/TapeStation, Qubit, NanoDrop).

• You have a high-level perspective with the ability to see the bigger picture and a desire to challenge the status quo.

• You are a team player, you have strong problem-solving, judgment and decision-making skills; you are known for your high level of attention to detail at scale in a fast-paced environment.

• You have strong communication skills including the ability to communicate with all levels within the organization; you are hands-on, self-directed, organized, conscientious.

• You have strong time management and organizational skills in a dynamic, continually changing environment; you have the ability to communicate effectively (both orally and in writing) with management, peers and individuals.

• You have the ability to work effectively, exhibit a professional manner and establish constructive working relationships.

About Roche Diagnostic’s Postdoctoral Program:

Elevate your research career to new heights with Roche Diagnostic’s Postdoctoral Program! Join a prestigious community of early career researchers and kick start your journey toward becoming a scientific leader in biotechnology and bioengineering. With competitive salaries and fully funded research expenses, you can dedicate yourself to groundbreaking research that aligns with Roche Diagnostics' strategic ambitions.

Our program is designed to empower recent PhD graduates to conduct world-class research, publish in top-tier journals, and network within our robust scientific community. By joining us, you will receive the mentorship and support necessary to develop into an independent scientific investigator. As an added benefit, our program will be tied into the long-standing Genentech Postdoc Program with access to world class seminars and networking opportunities with leading scientists. Apply now to Roche Diagnostic’s Postdoctoral Program and unlock your full potential!

The expected salary range for this position based on the primary location of Santa Clara, CA is $100,000 - $106,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.

This position is based onsite in Santa Clara, CA.

Relocation benefits are not provided for this role.

This position also qualifies for the benefits detailed at the link provided below:

Roche Benefits

#RMS2026NGS

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.

Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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