At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.
Are you passionate about designing and building AI-powered applications that bring together large language models, agentic workflows, and full stack engineering to solve real business problems?
Do you thrive working across the stack — AI/LLM integration, backend services, modern frontend frameworks, and cloud deployment — while staying curious about what GenAI can unlock next?
If so, Tech@Lilly is looking for an AI Full Stack Engineer to design, build, and scale AI-powered applications and full stack solutions across the enterprise.
As an AI Full Stack Engineer, you will design and develop AI-powered applications using Large Language Models, build Agentic AI workflows leveraging tools, reasoning, memory, and orchestration patterns, and develop Retrieval-Augmented Generation (RAG) solutions using enterprise knowledge sources. You will work across the full stack — building responsive frontend applications, scalable backend services and APIs, and cloud-native deployments on AWS — while integrating AI services with business applications and ensuring systems are secure, reliable, and production-ready.
What You’ll Be Doing:
- Design and build AI-powered applications using Large Language Models, agentic AI workflows, and Retrieval-Augmented Generation (RAG) solutions built on enterprise knowledge sources.
- Integrate AI services with business applications and external systems, and continuously evaluate, optimize, and monitor AI application performance and quality.
- Build responsive, modern frontend applications and scalable backend services and APIs, using reusable components and clean, maintainable code.
- Deploy and manage applications on cloud platforms (preferably AWS), building CI/CD pipelines, containerizing with Docker, and orchestrating workloads with Kubernetes.
- Design and manage SQL and NoSQL databases, integrate enterprise systems and third-party services, and ensure secure, compliant handling of data.
- Collaborate closely with product teams to translate business requirements into technical solutions, and implement monitoring, logging, and observability best practices.
What You Will Bring:
- Strong understanding of LLMs, Prompt Engineering, RAG, and Agentic AI concepts, with hands-on experience using frameworks such as LangGraph, LangChain, or LlamaIndex.
- Experience integrating AI models through OpenAI, Anthropic, Bedrock, Azure OpenAI, or equivalent services, along with working knowledge of vector databases and semantic search.
- Strong proficiency in Python, with experience building APIs using FastAPI, Flask, or similar frameworks, and a solid understanding of microservices architecture and API design.
- Practical experience with React and TypeScript, building modern, responsive user interfaces with strong attention to frontend performance and usability.
- Hands-on experience with AWS, Docker, and Kubernetes, and CI/CD implementation using GitHub Actions, Jenkins, GitLab, or similar tools, along with infrastructure deployment and environment management experience.
- Strong knowledge of relational databases such as PostgreSQL, MySQL, or SQL Server, with experience in NoSQL and vector databases preferred.
How You Will Succeed:
- Delivers production-ready AI applications with high quality and reliability.
- Independently drives features from design through deployment.
- Builds reusable and scalable solutions that can support multiple business teams.
- Improves developer productivity through automation and engineering best practices.
- Continuously explores and adopts emerging AI capabilities to solve business problems.
Basic Qualifications:
- 6-8 years of software engineering experience.
- At least 1-2 years of practical Generative AI experience.
- Strong Python + React + Cloud background. Proven deployments to production.
- Ability to work across the full technology stack independently.
Preferred Skills:
- Experience building enterprise AI copilots or intelligent assistants.
- Experience with Model Context Protocol (MCP) and AI tool integrations.
- Experience integrating with collaboration platforms such as Microsoft Teams, Jira, ServiceNow, or similar enterprise tools.
- Familiarity with AI observability, evaluations, and monitoring frameworks.
Will this position support sponsorship:
No
Travel percentage for this position:
0%-10%
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form () for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
#WeAreLilly